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Elizabeth Nolan

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Elizabeth Nolan
Born
Elizabeth Marie Nolan

1978 (age 45–46)
Alma materSmith College
Massachusetts Institute of Technology
AwardsPECASE
Scientific career
InstitutionsMassachusetts Institute of Technology
Harvard Medical School
ThesisFluorescent chemosensors for exploring zinc metalloneurochemistry and detecting mercury in aqueous solution (2006)
Doctoral advisorStephen J. Lippard
Websitechemistry.mit.edu/profile/elizabeth-marie-nolan

Elizabeth Marie Nolan (born 1978) is an American chemist and associate professor at Massachusetts Institute of Technology.

Early life and education

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Nolan was born in Niskayuna, New York.[1] She studied at Smith College, where she majored in chemistry and graduated magna cum laude in 2000.[1][2] During her undergraduate studies she minored in music and worked with Robert Linck on computational chemistry.[3] She studied the stereoelectronic effects in substituted alkanes.[4] Nolan was a member of Phi Beta Kappa.[1] She was awarded a Fulbright Program Scholarship and moved to France to study siderophore-iron complexes.[2] Nolan moved to Massachusetts Institute of Technology for her graduate studies, where she was supervised by Stephen J. Lippard.[1] She developed small molecule fluorescent sensors to monitor for zinc in neurobiology and mercury in aqueous solutions.[1][5] Together they filed a patent for Fluorescein-based metal sensors.[6] Nolan was a postdoctoral scientist at the Harvard Medical School, working with Christopher T. Walsh on the biosynthetic assembly of microcin E492m.[7] Microcin E492m is an antibiotic peptide that can target Gram-negative bacteria which express siderophore transporters.[1][7][8] She was awarded a $2.5 million National Institutes of Health grant in 2010 to study antibacterial peptides and zinc in innate immunity.[9] In 2011 she contributed to the book Letters to a Young Chemist.[4][10]

Research and career

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Nolan was appointed as an assistant professor at the department of chemistry at the Massachusetts Institute of Technology in 2014.[1] She explores the coordination chemistry of metal ions in biological systems; in particular how proteins destroy microbes by denying them metal nutrients.[3][11][12] She looks at the peptides and metalloproteins that are involved in mammalian immune response. Her current focus is on calprotectins and how they bind metals.[13][14] She used magnetic circular dichroism to study the binding of iron to human calprotectin.[15] Her group look to understand how Neuronal cells process and removes SOD1 point mutants.[16]

Nolan looks to design drugs to fight bacterial infections.[11] They study how immunity peptides that are encoded by the gene clusters that biosynthesize antibiotics which use metal ion transporters protect the organisms that produce them.[16] She proposes that hijacking the siderophore uptake pathways could allow new prevention and treatment against diseases.[citation needed] She worked with Manuela Raffatellu at University of California, Irvine to develop a new immunisation strategy against salmonella.[17] They target siderophores, a molecule that salmonella secretes to scavenge iron. Immunisation against siderophores led to the production of antibodies that reduced the growth of salmonella and other bacteria.[18] She is on the editorial board of Cell Chemical Biology.[19]

Patents

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Awards and honours

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References

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  1. ^ a b c d e f g "Elizabeth M. Nolan". web.mit.edu. Retrieved 2018-12-23.
  2. ^ a b "Smith Scholars With Places to Go". www.smith.edu. Retrieved 2018-12-23.
  3. ^ a b "Chemistry in Action: Liz Nolan | MIT OpenCourseWare | Free Online Course Materials". mit.uvt.rnu.tn. Archived from the original on 2018-12-24. Retrieved 2018-12-24.
  4. ^ a b Ghosh, Abhik (2011-04-04). Letters to a Young Chemist. John Wiley & Sons. ISBN 978-1-118-00708-2.
  5. ^ Nolan, Elizabeth M.; Lippard, Stephen J. (2009). "Small-Molecule Fluorescent Sensors for Investigating Zinc Metalloneurochemistry". Accounts of Chemical Research. 42 (1): 193–203. doi:10.1021/ar8001409. ISSN 0001-4842. PMC 2646817. PMID 18989940.
  6. ^ a b "US Patent for Fluorescein-based metal sensors Patent (Patent # 7,615,377 issued November 10, 2009) - Justia Patents Search". patents.justia.com. Retrieved 2018-12-23.
  7. ^ a b Nolan, Elizabeth M.; Fischbach, Michael A.; Koglin, Alexander; Walsh, Christopher T. (2007). "Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate". Journal of the American Chemical Society. 129 (46): 14336–14347. doi:10.1021/ja074650f. ISSN 0002-7863. PMC 2522288. PMID 17973380.
  8. ^ Huang, Kai; Zeng, Jianwei; Liu, Xueli; Jiang, Tianyu; Wang, Jiawei (2021-04-06). "Structure of the mannose phosphotransferase system (man-PTS) complexed with microcin E492, a pore-forming bacteriocin". Cell Discovery. 7 (1): 20. doi:10.1038/s41421-021-00253-6. ISSN 2056-5968. PMC 8021565. PMID 33820910.
  9. ^ Nolan, Elizabeth. "Antibacterial Peptides and Zinc in Innate Immunity and Mammalian Physiology". Grantome.
  10. ^ "Letters to a Young Chemist". Wiley.com. Retrieved 2018-12-24.
  11. ^ a b "Exploring the tug-of-war over metals during infection". MIT News. 4 January 2017. Retrieved 2018-12-23.
  12. ^ Nolan, Elizabeth. "CAREER: Coordination Chemistry of Zinc-Chelating S100 Proteins and Biochemistry Partnership with a Regional University". Grantome.
  13. ^ "Dr. Elizabeth Nolan - Department of Chemistry & Biochemistry - UMBC". chemistry.umbc.edu. Retrieved 2018-12-23.
  14. ^ MIT OpenCourseWare (26 February 2013), Chemistry in Action: Liz Nolan, retrieved 2018-12-23
  15. ^ Baker, Tessa M.; Nakashige, Toshiki G.; Nolan, Elizabeth M.; Neidig, Michael L. (2017). "Magnetic circular dichroism studies of iron(ii) binding to human calprotectin". Chemical Science. 8 (2): 1369–1377. doi:10.1039/c6sc03487j. ISSN 2041-6520. PMC 5361872. PMID 28451278.
  16. ^ a b c "Searle Scholars Program : Elizabeth M. Nolan (2011)". www.searlescholars.net. Retrieved 2018-12-23.
  17. ^ "A new approach against Salmonella and other pathogens". phys.org. Retrieved 2018-12-24.
  18. ^ Raffatellu, Manuela; Nolan, Elizabeth M.; George, Michael D.; Edwards, Robert A.; Perez-Lopez, Araceli; Zheng, Tengfei; Chairatana, Phoom; Sassone-Corsi, Martina (2016). "Siderophore-based immunization strategy to inhibit growth of enteric pathogens". Proceedings of the National Academy of Sciences. 113 (47): 13462–13467. Bibcode:2016PNAS..11313462S. doi:10.1073/pnas.1606290113. ISSN 1091-6490. PMC 5127304. PMID 27821741.
  19. ^ "Editorial Board: Cell Chemical Biology". www.cell.com. Retrieved 2018-12-23.
  20. ^ "US Patent Application for ENTEROBACTIN CONJUGATES AND USES THEREOF Patent Application (Application #20150105337 issued April 16, 2015) - Justia Patents Search". patents.justia.com. Retrieved 2018-12-23.
  21. ^ "US Patent for Enterobactin conjugates and uses thereof Patent (Patent # 9,902,986 issued February 27, 2018) - Justia Patents Search". patents.justia.com. Retrieved 2018-12-23.
  22. ^ "US Patent Application for SIDEROPHORE-BASED IMMUNIZATION AGAINST GRAM-NEGATIVE BACTERIA Patent Application (Application #20160022794 issued January 28, 2016) - Justia Patents Search". patents.justia.com. Retrieved 2018-12-23.
  23. ^ "US Patent for Siderophore-based immunization against gram-negative bacteria Patent (Patent # 10,039,816 issued August 7, 2018) - Justia Patents Search". patents.justia.com. Retrieved 2018-12-23.
  24. ^ "NIH Director's New Innovator Award - Funded Research". commonfund.nih.gov. 26 June 2013. Retrieved 2018-12-23.
  25. ^ "Eli Lilly Award in Biological Chemistry" (PDF). ACS Division of Biological Chemistry. Archived from the original (PDF) on 2020-10-09. Retrieved 2018-12-23.
  26. ^ "Michale Fee and Elizabeth Nolan win Teaching Prizes for Graduate and Undergraduate Education". MIT News. November 2016. Retrieved 2018-12-23.
  27. ^ "Denkewalter Lecture: Chemistry & Biochemistry, Department of : Loyola University Chicago". www.luc.edu. Retrieved 2018-12-23.
  28. ^ "White House honors 19 NSF-supported early-career researchers | NSF - National Science Foundation". www.nsf.gov. Retrieved 2018-12-23.
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